Major Thrust Areas: -
Medical Biotechnology: -
Hormone studies of Himalayan Inhabitants for thyroid & reproductive hormones (IDDs, Beta-thalassemia, Pre-Menstrual syndrome).
Conservation Biotechnology: -
Genetic Structure and Genetic Diversity of Himalayan Faunal & Floral resource for Conservation.
Plant Biotechnology: -
Scientific validation of plants of ethanomedicinal importance.
Exploration of plant tissue culture techniques for mass propagation and conservation of promising high value medicinal plants.
Harnessing untapped benefits of medicinal plants through biotechnological approaches and exploration of plant-pathogen interactions with special reference to Himalayan flora.
Deciphering the signaling pathways during abiotic and biotic stresses like plant-pathogen interactions, using genomics approaches
Microbial Biotechnology and Metagenomics:-
Biotechnological exploration of microorganisms for enzyme production, xenobiotic degradation, bioremediation of heavy metals and plant growth promotion.
Functional metagenomics and bacterial diversity assessment of soil, water, fermented food etc. by culture dependent and independent approaches.
Exploration of lichen diversity and production of natural dyes
Deciphering the structure and function of proteins of pathogenic bacteria and other parasites using macromolecular crystallography leading to structure based inhibitor design.
Comparative Genomics and Bio-informatics:
Comparing genomes of parasitic organisms to understand the novel pathways unique to pathogens and exploiting bio-informatics based tools to study their structure, function, annotation etc.
Research Projects: -
Bioinformatics Facility (BIF Centre) established by DBT, GoI, New Delhi, for the promotion of Biological Teaching through Bioinformatics (BTBI) Scheme of BTlSnet” (Cost approx Rs. 70 Lakh.) continues since 2007.
Effect of altitudinal variation on antioxidants, forskolin content and Genetic diversity of Coleus forskohlii from Uttarakhand and exploration of its anti-ageing potential, Uttarakhand Council for Biotechnology. (2017-2020, completed)
Prospecting for novel biocatalysts in a hot spring metagenome, DST, Govt. of India, Rs.18.74 lakh (2011-14, completed)
Characterization of psychrophilic bacterial diversity of Himalayan region in Uttarakhand, Uttarakhand Council for Biotechnology, Rs. 9.30 lakh (2012-2015, completed)
Physicochemical and microbiological assessment of some selected water springs of central Himalayan region, GBPIHED, Kosi, Katarmal, Rs. 14.63 lakh (2016-2019, completed)
To study the oxidative stress response on enzymatic, non-enzymatic antioxidants and analysis of Physio-morphological changes of Cicer arietinum, under the Heat-stress”, UGC-BSR Start-up Grant, 06 lakh, (2015-2017, completed)
Biochemical and structural characterization of the peroxiredoxins(s) involved in anti-oxidative defense in protozoan parasites Entamoeba histolytica and Trichomonas vaginalis. UGC-BSR Start-up Grant. 06 lakh, (2015-2017, completed).
Phylogeography and population diversity of Himalayan finches. Funded by Department of Science & Technology, New Delhi. Rs. 18 lakh (completed in 2010)